Adaptation of Methylobacterium extorquens to alternating carbon sources identifies the regulator CstR as an intersectional hub of cellular carbon metabolic dynamics and stress response
Eric L. Bruger, Isabella Ikobe, Chandler N. Hellenbrand, Uly Zigmund, Jannell V. Bazurto
This study identifies CstR as a key regulator in Methylobacterium extorquens that coordinates carbon source transitions and stress responses, with loss-of-function mutations improving metabolic flexibility but reducing stress resilience.
bioRxiv · Jul 1, 2026 · PreprintMicrobiology