A 3D Endothelium-on-a-Chip Model Uncovers Cx43-Dependent Glycolytic Shift and Endothelial Barrier Dysfunction in Diabetic Kidney Disease
Peter Lialios, Y. Kim, Isabella Trewhella, Komuraiah Myakala, Eleni P. Hughes, Xiaoxin X. Wang, Moshe Levi, Stella Alimperti
This study uses a 3D endothelium-on-a-chip model to show that Cx43-dependent glycolytic shifts contribute to endothelial barrier dysfunction in diabetic kidney disease.
bioRxiv · May 19, 2025 · PreprintBioengineering