Tumor-infiltrating CD27-IgD- regulatory B cells suppress cytotoxic CD8+T cell responses in renal cell carcinoma
Zara Baig, Isabella Withnell, Joseph Chi-Fung Ng, Christopher J. M. Piper, Hannah F. Bradford, Antonio Rullan, Edward H. Arbe-Barnes, Camila G.X. de Brito, Alessandro Di Tullio, Thomas J. Mitchell, Hans J. Stauss, Maxine G B Tran, Franca Fraternali, Claudia Mauri
The paper identifies CD27-IgD- regulatory B cells in renal cell carcinoma that suppress CD8+T cell responses, linking them to poor prognosis.
bioRxiv · Jul 8, 2025 · PreprintImmunology