Joseph Chi-Fung Ng

ImmunoMatch predicts cognate pairing of heavy and light immunoglobulin chains using a language model trained on paired sequences from human B cells.

This study designs framework mutations in antibodies to improve stability and function using a computational-experimental approach, showing that FW modifications can affect immunological functions beyond binding affinity.

The paper identifies CD27-IgD- regulatory B cells in renal cell carcinoma that suppress CD8+T cell responses, linking them to poor prognosis.

The paper investigates antibody class switching dynamics in a primary human immune response, revealing multistep progression and memory B cell subtype dependence beyond IGHG2.

TITINdb2 expands variant annotation and structural information for titin protein variants associated with myopathies.

VCAb provides a web tool for antibody engineering by annotating antibody structures, isotypes, and mutation impacts across species.

The paper identifies a DNA mutational signature linked to damaging protein variants, showing it is under-sampled in tumor data and can predict variant impact using DMS data.

This study identifies molecular differences between pathogenic and population missense variants by analyzing their effects on protein structure and function, revealing distinct patterns in protein domains and cellular processes.