Allosteric inhibition of Aurora-A kinase by a synthetic VNAR nanobody
Selena G Burgess, Arkadiusz Oleksy, Tommaso Cavazza, Mark W Richards, Isabelle Vernos, David Matthews, Richard Bayliss
This paper describes the development of an allosteric inhibitor for Aurora-A kinase using a synthetic VNAR nanobody, showing it stabilizes an inactive conformation distinct from the activator TPX2.
Open Biology · Jul 1, 2016Peer-reviewedBiochemistry