Hyperglycemia worsens smooth muscle foam cell formation through PI3Kgamma-dependent defective autophagy
Honora Labrana, Amandine Wahart, Kévin Cormier, Romain Solinhac, Audrey Swiader, Isra Mentouri, Natalia F. Smirnova, Nicole Malet, Stéphanie Gayral, Damien Ramel, Nathalie Augè, Muriel Laffargue
This study shows hyperglycemia impairs autophagy in smooth muscle cells, promoting foam cell formation via PI3Kgamma and TFEB phosphorylation, suggesting therapeutic potential for PI3Kgamma inhibitors in diabetes-related cardiovascular disease.
bioRxiv · Jan 21, 2025 · PreprintCell Biology