Chromatin Remodeling Drives Immune-Fibroblast Crosstalk in Heart Failure Pathogenesis
Michael Alexanian, Arun Padmanabhan, Tomohiro Nishino, Joshua G. Travers, Lin Ye, Clara Youngna Lee, Nandhini Sadagopan, Yu Huang, Angelo Pelonero, Kirsten Auclair, Ada Zhu, Bárbara González‐Terán, Will Flanigan, Charis Kee-Seon Kim, Koya Lumbao-Conradson, , Deepak Srivastava
The paper identifies BRD4-dependent immune-fibroblast crosstalk via IL1B in heart failure, showing IL1B inhibition reduces fibroblast activation and improves cardiac function.
bioRxiv · Jan 6, 2023 · PreprintMolecular Biology