Will Flanigan

This study identifies branched-chain amino acid fermentation as an alternative electron sink in mammals under hypoxia, with implications for reductive stress and sperm motility.

This study shows that red blood cells act as a primary glucose sink under hypoxia, improving glucose tolerance and offering therapeutic potential for diabetes.

This study shows systemic hypoxia reduces solid tumor growth across multiple cancer types without resistance, through purine metabolism suppression and can be pharmacologically induced.

The paper uses a CRISPRi screen to identify basigin loss as protective in cardiac hypoxia by enhancing ATP maintenance and survival.

The paper identifies genetic regulators of neuronal survival across different metabolic environments using CRISPRi screens in human neurons.

The paper identifies BRD4-dependent immune-fibroblast crosstalk via IL1B in heart failure, showing IL1B inhibition reduces fibroblast activation and improves cardiac function.