Angelo Pelonero

Neural Crest-Derived Endocardial Cells Required for Heart Valve Development

The paper identifies a rare population of neural crest-derived endocardial cells essential for heart valve development in mice and humans, showing their role in valve morphogenesis through Pthlh signaling.

A Compact Regulatory Logic Governs Fibroblast Cell State Plasticity in Fibrosis

The paper identifies a compact regulatory logic governing fibroblast plasticity in fibrosis by analyzing enhancer repression and gene perturbations across multiple tissues.

Eed controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crest

This study shows that Eed is essential for craniofacial osteoblast differentiation and mesenchymal proliferation in neural crest cells, identified through mouse genetics, single-cell RNA sequencing, and epigenetic profiling.

Single Cell Multimodal Analyses Reveal Epigenomic and Transcriptomic Basis for Birth Defects in Maternal Diabetes

The paper uses single-cell multimodal analyses to show how maternal diabetes alters epigenomic and transcriptomic states in cardiac and craniofacial progenitors, leading to developmental defects.

Chromatin Remodeling Drives Immune-Fibroblast Crosstalk in Heart Failure Pathogenesis

The paper identifies BRD4-dependent immune-fibroblast crosstalk via IL1B in heart failure, showing IL1B inhibition reduces fibroblast activation and improves cardiac function.

CSDE1 is a Post-Transcriptional Regulator of the LDL Receptor

A genome-wide CRISPR screen identifies CSDE1 as a key regulator of hepatic LDLR mRNA decay in vivo, making it a promising target for heart disease.

Single Cell Epigenetics Reveal Cell-Cell Communication Networks in Normal and Abnormal Cardiac Morphogenesis

The paper uses single-cell epigenomics and machine learning to model cell-cell communication networks in cardiac development and identify dysregulation in TBX1 deletion.

A Transcriptional Switch Governing Fibroblast Plasticity Underlies Reversibility of Chronic Heart Disease

The paper identifies a reversible transcriptional switch in cardiac fibroblasts that governs fibroblast plasticity and contributes to chronic heart disease, with MEOX1 as a key regulator.