Synthetic BiologybioRxivPreprint
Unlocking de novo antibody design with generative artificial intelligence
Amir Shanehsazzadeh, Matt McPartlon, George W. Kasun…·Sharrol T. Bachas
Deep generative models combined with high-throughput screening design de novo anti-HER2 antibodies without further optimization, yielding nanomolar binders functionally comparable or superior to trastuzumab.
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