MicrobiologybioRxiv
Generation and evaluation of protease inhibitor-resistant SARS-CoV-2 strains
Hawa Sophia Bouzidi, Jean-Sélim Driouich, Raphaëlle Klitting…·Franck Touret
The paper generates and evaluates SARS-CoV-2 mutants resistant to protease inhibitors nirmatrelvir and ensitrelvir, showing in vitro and in vivo resistance and linking M49L mutation prevalence to Xocova(R) use.
DOI 10.1016/j.antiviral.2024.105814