Inhibition of the serine protease HtrA1 by SerpinE2 suggests an extracellular proteolytic pathway in the control of neural crest migration
Edgar M. Pera, Josefine Nilsson-De Moura, Yuriy Pomeshchik, Laurent Roybon, Ivana Milas
The paper shows that SerpinE2 inhibits HtrA1 protease activity, which in turn degrades Syndecan-4, affecting neural crest cell migration in Xenopus embryos.
eLife · Oct 12, 2023Peer-reviewedDevelopmental Biology