Laurent Roybon

A convergent metabolic-kinase signaling axis links Parkinson s disease and multiple system atrophy

This paper identifies shared metabolic and kinase signaling disruptions in Parkinson's disease and multiple system atrophy using patient-derived models and postmortem tissue.

Unique transcriptional profiles of adult human immature neurons in healthy aging, Alzheimer's disease, and cognitive resilience

The paper identifies unique transcriptional profiles of immature neurons in aged human hippocampus across healthy, Alzheimer's disease, and resilient conditions, linking them to homeostasis and cognitive resilience.

Redefining Parkinson's Disease by Dysregulated Genetic Networks in Distinct Cell Types

This paper identifies six PD subgroups based on cell-type-specific genetic networks and links NRG6 to reduced myelin integrity in oligodendrocytes.

TNFa hinders FGF4 efficacy to mitigate ALS astrocyte dysfunction and cGAS-STING pathway-induced innate immune reactivity

This study shows that FGF4 reduces ALS astrocyte reactivity but fails to protect motor neurons in a mouse model, while TNF exacerbates astrocyte dysfunction.

Inhibition of the serine protease HtrA1 by SerpinE2 suggests an extracellular proteolytic pathway in the control of neural crest migration

The paper shows that SerpinE2 inhibits HtrA1 protease activity, which in turn degrades Syndecan-4, affecting neural crest cell migration in Xenopus embryos.

Proteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction, progression, and prion-like spread of Alzheimer s disease pathogenesis

The paper uses proteomic analysis of patient iPSC-derived brain cells and post-mortem hippocampal tissue to study early AD pathogenesis and prion-like spread.