The Metabolic Scope Theory of Aging: Rising Mitochondrial Impedance Compresses Metabolic Reserve to Constrain Lifespan
Gilad Lehmann, Yona Greenman, Izhar Shtrom, Yossi Anis, Joseph Lehmann, Naftali Stern, Gabi Shefer
This paper proposes the Metabolic Scope Theory of Aging (MSTA) to explain lifespan variation by linking mitochondrial bioenergetic reserve, stability, and pace across species.
bioRxiv · Jun 23, 2026 · PreprintPhysiology