Gabi Shefer

The Metabolic Scope Theory of Aging: Rising Mitochondrial Impedance Compresses Metabolic Reserve to Constrain Lifespan

This paper proposes the Metabolic Scope Theory of Aging (MSTA) to explain lifespan variation by linking mitochondrial bioenergetic reserve, stability, and pace across species.

Epigenetic aging waves:Artificial intelligence detects clustering of switch points in DNA methylation rate in defined sex-dependent age periods

The paper uses machine learning to identify age-related switch points in DNA methylation trends, revealing three sex-dependent waves of epigenetic aging.

Deconvolution of the epigenetic age discloses distinct inter-personal variability in epigenetic aging patterns

The paper deconvolves epigenetic age to identify CpG sites responsible for accelerated and decelerated aging, revealing inter-personal variability in aging patterns.