Longitudinal single-cell transcriptional profiling identifies dynamic neurodegenerative mechanisms in Christianson Syndrome rat
Hasib Aamir Riaz, Smijin Karthully Soman, J Devlin, Gajendra Kumar, Youjin Lee, Eric M. Morrow
This study uses single-cell RNA sequencing in a CS rat model to identify dynamic neurodegenerative mechanisms, revealing early mitochondrial dysfunction and microglial activation overlapping with Alzheimer's disease.
bioRxiv · Oct 20, 2026 · PreprintNeuroscience