Youjin Lee

This study uses single-cell RNA sequencing in a CS rat model to identify dynamic neurodegenerative mechanisms, revealing early mitochondrial dysfunction and microglial activation overlapping with Alzheimer's disease.

The paper shows that endosome maturation is regulated by proton signaling through NHE6 and pH-dependent Rab7 cycling, with implications for neurodegeneration.

SpaceTravLR identifies spatial functional microniches by modeling genetic perturbations across spatially resolved molecular networks, validated experimentally in a murine model.

This paper describes a method to efficiently generate genetically modified primary human myeloid cells using CRISPR-Cas9 RNP nucleofection, demonstrating its utility in studying HIV-1 infection and myeloid cell biology.