Hasib Aamir Riaz

Longitudinal single-cell transcriptional profiling identifies dynamic neurodegenerative mechanisms in Christianson Syndrome rat

This study uses single-cell RNA sequencing in a CS rat model to identify dynamic neurodegenerative mechanisms, revealing early mitochondrial dysfunction and microglial activation overlapping with Alzheimer's disease.

Endosome maturation is orchestrated by inside-out proton signaling through a Na+/H+ exchanger and pH-dependent Rab GTPase cycling

The paper shows that endosome maturation is regulated by proton signaling through NHE6 and pH-dependent Rab7 cycling, with implications for neurodegeneration.