Branched DNA Processing by a Thermostable CAS-Cas4 from Thermococcus onnurineus: Expanding Biochemical Landscape of Nuclease Activity
M.K. Jain, Asish Kumar Pattnayak, Sakshi Aggarwal, Praveen Rai, J Kavya, Sanjeev Kumar Chandrayan, Manisha Goel, Vineet Gaur
This paper characterizes the biochemical properties of TON_0321, a CAS-Cas4 protein from Thermococcus onnurineus, revealing its 5' to 3' exonuclease and structure-dependent endonuclease activities.
Journal of Biological Chemistry · Sep 12, 2025Peer-reviewedBiochemistry