Complement C1q-dependent engulfment of alpha-synuclein induces ENS-resident macrophage exhaustion and accelerates Parkinsons-like gut pathology
Phillip M. Mackie, J Koshy, M Bhogade, T Hammoor, William Hachmeister, Grace M. Lloyd, Giavanna Paterno, MacKenzie L. Bolen, Malú G. Tansey, Benoit I. Giasson, Habibeh Khoshbouei
This study shows that C1q-dependent engulfment of alpha-synuclein by ENS macrophages leads to their exhaustion and worsens Parkinson's-like gut pathology.
bioRxiv · Oct 24, 2023 · PreprintNeuroscience