Benoit I. Giasson

This study shows that alpha-synuclein elevates firing rates and impairs homeostatic regulation in SNc dopamine neurons, but not VTA neurons, before neurodegeneration occurs.

This study identifies a PERK-B/DLX1 pathway as a novel driver of tau pathology in human PSP and flies, showing DLX1 promotes tau toxicity.

This study shows that C1q-dependent engulfment of alpha-synuclein by ENS macrophages leads to their exhaustion and worsens Parkinson's-like gut pathology.

The paper investigates how α-synuclein dysregulation affects D2 receptor activity in dopamine neurons, showing it contributes to neuronal vulnerability and identifies potential therapeutic targets.

This study develops a transgenic mouse model expressing human alpha-synuclein in noradrenergic neurons, revealing LC pathology and non-motor PD features.