ALDH2 dysfunction accelerates ESCC pathogenesis
S. Flashner, M. Shimonosono, N. Matsuura, S. Ohashi, A. J. Klein-Szanto, J. A. Diehl, C.-H. Chen, H. Nakagawa
This study shows that ALDH2 dysfunction accelerates ESCC pathogenesis by increasing CSCs, ROS, and DNA damage, and reduces response to cisplatin chemotherapy.
bioRxiv · Apr 3, 2023 · PreprintCancer Biology