Hierarchical determinants of the oxidation-induced mutational landscape in human cells.
C. Cordero, K. P. M. Mehta, T. M. Weaver, J. A. Ling, B. D. Freudenthal, D. Cortez, S. A. Roberts
This study identifies factors influencing 8-oxoG-induced mutagenesis in human cells, revealing a hierarchical DNA repair network and chromatin structure effects on mutation patterns.
bioRxiv · Apr 8, 2024 · PreprintCancer Biology