Author

T. M. Weaver

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:protein folding & dynamics· 3 Assay:structural biology· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:fluorescence / live-cell microscopy· 2 Organism:human· 2

Frequent Co-Authors

B. D. Freudenthal· 6 shared B. Van Houten· 2 shared P. Agarwal· 2 shared T. H. Khoang· 2 shared V. Roginskaya· 2 shared A. C. Drohat· 1 shared B. L. Schnable· 1 shared C. Cordero· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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6 shared papersBiochemistry

B. D. Freudenthal

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Author profile →

6 papers

Recent·Most cited

Hierarchical determinants of the oxidation-induced mutational landscape in human cells.

C. Cordero, K. P. M. Mehta, T. M. Weaver, J. A. Ling, B. D. Freudenthal, D. Cortez, S. A. Roberts

This study identifies factors influencing 8-oxoG-induced mutagenesis in human cells, revealing a hierarchical DNA repair network and chromatin structure effects on mutation patterns.

bioRxiv · Apr 8, 2024 · PreprintCancer Biology

Single-molecule analysis of purified proteins and nuclear extracts: insights from 8-oxoguanine glycosylase 1

M. Schaich, T. M. Weaver, V. Roginskaya, B. D. Freudenthal, B. Van Houten

This study compares single-molecule DNA binding dynamics of purified OGG1 and nuclear extracts using SMADNE, revealing differences in undamaged DNA binding and increased binding lifetime for a catalytically dead variant in nuclear extracts.

bioRxiv · Nov 1, 2023Biochemistry

Single-molecule analysis reveals TDG exhibits multiple modes of linear diffusion to process 5-formylcytosine.

B. L. Schnable, M. A. Schaich, V. Roginskaya, L. P. Leary, T. M. Weaver, B. D. Freudenthal, A. C. Drohat, B. Van Houten

This study uses single-molecule fluorescence to show TDG uses multiple diffusion modes to search for DNA lesions and how its structure affects nucleosome interactions.

bioRxiv · Oct 4, 2023Biophysics

Structural basis for APE1 processing DNA damage in the nucleosome

T. M. Weaver, N. M. Hoitsma, J. J. Spencer, L. Gakhar, N. J. Schnicker, B. D. Freudenthal

This study reveals how APE1 processes DNA damage in nucleosomes by bending DNA to access AP sites, with efficiency depending on site exposure.

bioRxiv · Mar 9, 2022Biochemistry

Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1

T. M. Weaver, T. H. Click, T. H. Khoang, T. M. Washington, P. Agarwal, B. D. Freudenthal

This study investigates how Rev1 discriminates between nucleotides during translesion synthesis, showing structural differences in hydrogen bonding and sugar pucker when using dCTP versus rCTP.

bioRxiv · Dec 1, 2021Biochemistry

Visualizing Rev1 Catalyze Protein-template DNA Synthesis

T. M. Weaver, L. M. Cortez, T. H. Khoang, M. T. Washington, P. Agarwal, B. D. Freudenthal

This study uses time-lapse X-ray crystallography to visualize Rev1's mechanism of catalyzing protein-template DNA synthesis, revealing key steps in nucleotide incorporation and product release.

bioRxiv · Apr 10, 2020Biochemistry