Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation
J. A. Macpherson, A. Theisen, L. Masino, L. Fets, P. C. Driscoll, V. Encheva, A. P. Snijders, S. R. Martin, J. Kleinjung, P. E. Barran, F. Fraternali, D. Anastasiou
The paper investigates how PKM2 activity is regulated by simultaneous binding of activating and inhibiting ligands, revealing a mechanism for integrating allosteric inputs.
bioRxiv · Jul 26, 2018Biochemistry