Author

P. C. Driscoll

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

A. Mendez-Lucas· 1 shared A. P. Snijders· 1 shared A. Theisen· 1 shared C. Xie· 1 shared D. Anastasiou· 1 shared F. Fraternali· 1 shared J. A. Macpherson· 1 shared J. I. MacRae· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. Mendez-Lucas

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Author profile →

2 papers

Recent·Most cited

Identifying strategies to target the metabolic flexibility of tumours.

A. Mendez-Lucas, W. Lin, P. C. Driscoll, N. Legrave, L. Novellasdemunt Vilaseca, C. Xie, M. Charles, Z. Wilson, N. P. Jones, S. G. Rayport, M. Rodriguez-Justo, V. S. W. Li, J. I. MacRae, N. Hay, X. Chen, M. Yuneva

The paper identifies compensatory metabolic mechanisms in tumours and shows that targeting these can improve therapeutic outcomes.

bioRxiv · Jan 6, 2020Cancer Biology

Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation

J. A. Macpherson, A. Theisen, L. Masino, L. Fets, P. C. Driscoll, V. Encheva, A. P. Snijders, S. R. Martin, J. Kleinjung, P. E. Barran, F. Fraternali, D. Anastasiou

The paper investigates how PKM2 activity is regulated by simultaneous binding of activating and inhibiting ligands, revealing a mechanism for integrating allosteric inputs.

bioRxiv · Jul 26, 2018Biochemistry