Author

J. Kleinjung

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

D. Anastasiou· 2 shared L. Fets· 2 shared A. Asuaje· 1 shared A. Jain· 1 shared A. P. Snijders· 1 shared A. Theisen· 1 shared F. Fraternali· 1 shared F. Grimm· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

D. Anastasiou

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2 papers

Recent·Most cited

GOT1 primes the cellular response to hypoxia by supporting glycolysis and HIF1α stabilisation

F. Grimm, A. Asuaje, A. Jain, M. Silva dos Santos, J. Kleinjung, P. M. Nunes, S. Gehrig, L. Fets, J. MacRae, D. Anastasiou

This study identifies GOT1 as a key factor in priming cells for hypoxic adaptation by enhancing glycolysis and HIF1α stabilization before full HIF1 activation.

bioRxiv · Sep 6, 2023 · PreprintCancer Biology

Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation

J. A. Macpherson, A. Theisen, L. Masino, L. Fets, P. C. Driscoll, V. Encheva, A. P. Snijders, S. R. Martin, J. Kleinjung, P. E. Barran, F. Fraternali, D. Anastasiou

The paper investigates how PKM2 activity is regulated by simultaneous binding of activating and inhibiting ligands, revealing a mechanism for integrating allosteric inputs.

bioRxiv · Jul 26, 2018Biochemistry