A binary arginine methylation switch on histone H3 Arginine 2 regulates its interaction with WDR5
B. M. Lorton, R. K. Harijan, E. S. Burgos, J. B. Bonnano, S. C. Almo, D. Shechter
The paper investigates how arginine methylation states of H3R2 regulate its interaction with WDR5, revealing a binary switch mechanism where me2a blocks binding while me0/me1/me2s allow it.
bioRxiv · Jan 13, 2020Biochemistry