Author

S. C. Almo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6 Biophysics· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 5 Organism:human· 3 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Assay:structural biology· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

J. B. Bonanno· 4 shared A. B. Massimi· 2 shared A. Celikgil· 2 shared A. Ghosh· 2 shared D. Shechter· 2 shared J. H. Lee· 2 shared K. Chandran· 2 shared N. C. Morano· 2 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersBiochemistry

J. B. Bonanno

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Unique Binding and Stabilization Mechanisms Employed By and Engineered Into Nanobodies.

N. E. Ketaren, P. C. Fridy, V. Malashkevich, T. Sanyal, M. Brilliantes, M. K. Thompson, D. A. Orens, J. B. Bonanno, a. Sali, S. C. Almo, B. T. Chait, M. P. Rout

This study identifies mechanisms enabling nanobodies to bind antigens with high affinity and stability, revealing a conserved region critical for their function and suggesting strategies for their optimization.

bioRxiv · Oct 22, 2023 · PreprintBiochemistry

SARS-CoV-2 multi-antigen protein microarray for detailed characterization of antibody responses in COVID-19 patients

A. Celikgil, A. B. Massimi, A. Nakouzi, N. G. Herrera, N. C. Morano, J. H. Lee, H. a. Yoon, S. J. Garforth, S. C. Almo

This study develops a SARS-CoV-2 multi-antigen protein microarray to analyze antibody responses in COVID-19 patients, showing higher S IgG levels and reactivity to the S1 RBD but not S2 heptad repeat domain.

bioRxiv · Oct 14, 2022Biochemistry

Two point mutations in protocadherin-1 disrupt Andes hantavirus recognition and afford protection against lethal infection

M. M. Slough, R. Li, A. S. Herbert, G. Lasso, A. I. Kuehne, R. R. Bakken, S. R. Monticelli, Y. Liu, A. Ghosh, A. M. Moreau, X. Zeng, S. C. Almo, J. M. Dye, R. K. Jangra, Z. Wang, K. Chandran

The paper identifies two point mutations in PCDH1 that disrupt ANDV recognition and protect against lethal infection in Syrian hamsters.

bioRxiv · Jul 19, 2022Microbiology

HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160

W. Liu, T.-F. Chou, S. C. Garrett-Thomson, G.-Y. Seo, E. Fedorov, U. A. Ramagopa, J. B. Bonanno, K. Kakugawa, H. Cheroutre, M. Kronenberg, S. C. Almo

The paper determines HVEM structures and generates mutants to reveal distinct functions of binding to LIGHT and BTLA/CD160 in immune responses.

bioRxiv · Jun 16, 2021Immunology

The Phaeodactylum tricornutum Diaminopimelate Decarboxylase was Acquired via Horizontal Gene Transfer from Bacteria and Displays Substrate Promiscuity

V. A. Bielinski, J. K. Brunson, A. Ghosh, M. A. Moosburner, E. A. Garza, Z. Fussy, J. Bai, S. M. K. McKinnie, B. Moore, A. E. Allen, S. C. Almo, C. L. Dupont

This paper identifies a horizontally transferred DAPDC gene in Phaeodactylum tricornutum that exhibits substrate promiscuity in lysine biosynthesis.

bioRxiv · Oct 1, 2020 · PreprintBiochemistry

Inhibition of SARS-CoV-2 polymerase by nucleotide analogs: a single moleculeperspective

M. Seifert, S. C. Bera, P. van Nies, R. N. Kirchdoerfer, A. Shannon, T.-T.-N. Le, X. Meng, H. Xia, J. M. Wood, L. D. Harris, F. S. Papini, J. J. Arnold, S. C. Almo, T. L. Grove, P.-Y. Shi, , D. Dulin

This study investigates how nucleotide analogs like Remdesivir affect SARS-CoV-2 polymerase activity using single-molecule techniques, revealing backtracking rather than termination and evasion of ddhCTP.

bioRxiv · Aug 6, 2020 · PreprintBiophysics

Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis

N. G. Herrera, N. C. Morano, A. Celikgil, G. I. Georgiev, R. J. Malonis, J. H. Lee, K. Tong, O. Vergnolle, A. B. Massimi, L. Y. Yen, A. J. Noble, M. Kopylov, J. B. Bonanno, S. C. Garrett-Thomson, D. B. Hayes, , S. C. Almo

This study evaluates the production, characterization, and antigenicity of SARS-CoV-2 S protein constructs in two cell lines, showing high-quality yields and consistent behavior across assays.

bioRxiv · Jun 14, 2020Biochemistry

Structure of a Single Chain H2A/H2B Dimer

C. Warren, J. B. Bonanno, S. C. Almo, D. Shechter

The paper creates a single-chain H2A/H2B dimer and determines its structure, showing it resembles nucleosomal H2A/H2B, providing a tool for studying H2A/H2B-interacting proteins.

bioRxiv · Mar 15, 2020Biochemistry

A binary arginine methylation switch on histone H3 Arginine 2 regulates its interaction with WDR5

B. M. Lorton, R. K. Harijan, E. S. Burgos, J. B. Bonnano, S. C. Almo, D. Shechter

The paper investigates how arginine methylation states of H3R2 regulate its interaction with WDR5, revealing a binary switch mechanism where me2a blocks binding while me0/me1/me2s allow it.

bioRxiv · Jan 13, 2020Biochemistry