Epigenetic remodeling during monolayer cell expansion reduces therapeutic potential
A. Scott, E. Casas, S. E. Schneider, A. Swearingen, C. Van Den Elzen, B. Seelbinder, J. Barthold, J. Kugel, J. L. Stern, K. Foster, N. Emery, J. Brumbaugh, C. Neu
This study shows that mechanical memory in chondrocytes is encoded in chromatin architecture, affecting their fate and therapeutic potential after expansion.
bioRxiv · Dec 14, 2021 · PreprintBioengineering