Methylome-based cell-of-origin modeling (Methyl-COOM) identifies aberrant expression of immune regulatory molecules in CLL
J. A. Wierzbinska, R. Toth, N. Ishaque, K. Rippe, J.-P. Mallm, L. Klett, D. Mertens, T. Zenz, T. Hielscher, M. Seifert, R. Kueppers, Y. Assenov, P. Lutsik, S. Stilgenbauer, P. M. Roessner, , D. B. Lipka
This study introduces Methyl-COOM, a method to identify cell-of-origin and CLL-specific epigenetic aberrations by analyzing DNA methylation patterns.
bioRxiv · Feb 4, 2020Cancer Biology