K. Rippe

Cell-state plasticity drives heterogeneity in Group 3/4 medulloblastoma

This study identifies cell-state plasticity as a driver of heterogeneity in Group 3/4 medulloblastomas, showing that transcription factor perturbation can redirect tumor cells along different differentiation trajectories.

Medulloblastoma oncogene aberrations are not involved in tumor initiation, but essential for disease progression and therapy resistance

The paper uses single-cell technologies to show that large-scale chromosomal aberrations drive medulloblastoma initiation, while single-gene oncogenic events like MYC contribute to progression and therapy resistance.

Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage

The paper uses single-cell transcriptomics to show how two compartments in medulloblastoma are connected through a migrating precursor stage, revealing spatial and developmental links between proliferating and differentiated tumor cells.

Transcription activation is enhanced by multivalent interactions independent of phase separation

The paper shows that multivalent interactions enhance transcription activation by stabilizing chromatin binding and recruiting co-activators, independent of phase separation.

Hematopoietic stem cells fail to regenerate following inflammatory challenge.

This study shows that repeated inflammatory challenges lead to progressive depletion of functional HSCs with no recovery, contributing to age-related hematopoietic decline.

Methylome-based cell-of-origin modeling (Methyl-COOM) identifies aberrant expression of immune regulatory molecules in CLL

This study introduces Methyl-COOM, a method to identify cell-of-origin and CLL-specific epigenetic aberrations by analyzing DNA methylation patterns.

Dissecting intratumor heterogeneity of nodal B cell lymphomas on the transcriptional, genetic, and drug response level

This study examines intratumor heterogeneity in B cell lymphomas by analyzing transcriptional, genetic, and drug response profiles across malignant subclones and immune cells.

Single-cell transcriptomes of the aging human skin reveal loss of fibroblast priming

The paper uses single-cell RNA sequencing to analyze fibroblast subpopulations in young and old human skin, finding that aging reduces fibroblast priming and alters their interactions with other skin cells.

TelNet - a database for human and yeast genes involved in telomere maintenance

TelNet is a database that compiles over 2,000 human and 1,100 yeast genes involved in telomere maintenance, providing annotations and search tools for TM-related research.

Real-Time Observation Of Light-Controlled Transcription In Living Cells

This study introduces BLInCR, a tool for real-time observation of light-controlled transcription in living cells, showing rapid RNA production and biphasic activation kinetics.

Retrieving chromatin patterns from deep sequencing data using correlation functions

The paper introduces MCORE, a method to quantify and compare chromatin patterns across length scales using correlation functions, applied to mouse chromatin data.