M. Seifert

The Gut Microbiome Controls Liver Tumors via the Vagus Nerve

This study shows that gut microbiota influence liver tumor growth and behavior through the vagus nerve, with cholinergic signaling and CD8+ T cells playing key roles.

A single-cell multi-omic and spatial atlas of B cell lymphomas reveals differentiation drives intratumor heterogeneity

This study reveals that cellular differentiation drives intratumor heterogeneity in B-cell lymphomas, with distinct maturation states associated with different survival outcomes.

Temperature-dependent twist of double-stranded RNA probed by magnetic tweezers experiments and molecular dynamics simulations

This study investigates how temperature affects the twist of double-stranded RNA using magnetic tweezers and molecular dynamics simulations, finding RNA unwinds more than DNA with increasing temperature.

"Wissenschaft fürs Wohnzimmer" - two years of interactive, scientific livestreams weekly on YouTube

The paper reports on two years of weekly YouTube livestreams discussing climate change and biodiversity, showing growth in views and subscriptions through diverse presenters and interactive content.

A heterogeneous pool of tumor precursor cells with self-replenishing and tumor-originating properties in Chronic Lymphocytic Leukemia

The paper identifies a heterogeneous subpopulation of CLL-related B cells with self-replenishing and tumor-initiating properties that contribute to disease progression and clonal evolution.

Quantitative parameters of bacterial RNA polymerase open-complex formation, stabilization and disruption on a consensus promoter

The paper quantifies the kinetics of bacterial RNA polymerase open-complex formation, stabilization, and disruption on a consensus promoter using single-molecule magnetic tweezers.

The nucleotide addition cycle of the SARS-CoV-2 polymerase

This study describes the mechanochemical behavior of the SARS-CoV-2 polymerase using magnetic tweezers, revealing three catalytic conformations and a thermal ratchet mechanism for nucleotide incorporation.

Human neonatal B cell immunity differs from the adult version by conserved Ig repertoires and rapid, but transient response dynamics

This study shows that human cord blood B cells are mature and functional but have distinct transcriptional programs and rapid, transient response dynamics compared to adult B cells.

Inhibition of SARS-CoV-2 polymerase by nucleotide analogs: a single moleculeperspective

This study investigates how nucleotide analogs like Remdesivir affect SARS-CoV-2 polymerase activity using single-molecule techniques, revealing backtracking rather than termination and evasion of ddhCTP.

Methylome-based cell-of-origin modeling (Methyl-COOM) identifies aberrant expression of immune regulatory molecules in CLL

This study introduces Methyl-COOM, a method to identify cell-of-origin and CLL-specific epigenetic aberrations by analyzing DNA methylation patterns.

Temperature controlled high-throughput magnetic tweezers show striking difference in activation energies of replicating viral RNA-dependent RNA polymerases.

This study uses temperature-controlled magnetic tweezers to compare replication kinetics of RdRps from three RNA viruses, finding temperature-dependent activation differences.

High-yield fabrication of DNA and RNA scaffolds for single molecule force and torque spectroscopy experiments.

The paper presents new protocols for high-yield fabrication of DNA and RNA scaffolds for single molecule force and torque spectroscopy experiments, showing improved efficiency over standard methods.