GRK specificity and beta gamma dependency determines a GPCR`s potential in biased agonism
E. S. Matthees, J. C. Filor, N. Jaiswal, M. Reichel, N. Youssef, J. Drube, A. Godbole, C. Hoffmann
This paper shows that GRK2/3's interaction with Gβγ is essential for β-arrestin2 recruitment to GPCRs, linking G protein activation to biased agonism potential.
bioRxiv · Jul 14, 2023Pharmacology & Toxicology