IRF1 regulates self-renewal and stress-responsiveness to support hematopoietic stem cell maintenance
A. J. Rundberg Nilsson, H. Xian, S. Shalapour, J. Cammenga, M. Karin
This study identifies IRF1 as a master regulator of hematopoietic stem cell (HSC) self-renewal and stress responses, showing its role in maintaining HSC function and its relevance in AML patient stratification.
bioRxiv · Jan 24, 2023Cell Biology