Cell BiologybioRxiv
IRF1 regulates self-renewal and stress-responsiveness to support hematopoietic stem cell maintenance
A. J. Rundberg Nilsson, H. Xian, S. Shalapour…·M. Karin
This study identifies IRF1 as a master regulator of hematopoietic stem cell (HSC) self-renewal and stress responses, showing its role in maintaining HSC function and its relevance in AML patient stratification.
DOI 10.1126/sciadv.adg5391