Author

S. Shalapour

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

H. Sugimoto· 2 shared K. K. Mahadevan· 2 shared K. M. McAndrews· 2 shared M. Karin· 2 shared N. T. Ryujin· 2 shared R. Kalluri· 2 shared A. J. Rundberg Nilsson· 1 shared A. M. Dyevoich· 1 shared

Activity by Year

2023-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersImmunology

H. Sugimoto

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Development of an engineered extracellular vesicles-based vaccine platform for combined delivery of mRNA and protein to induce functional immunity

X. Luo, K. M. McAndrews, K. A. Arian, S. J. Morse, V. Boeker, S. V. Kumbhar, Y. Hu, K. K. Mahadevan, K. A. Church, S. Chitta, N. T. Ryujin, J. Hensel, J. Dai, D. P. Dowlatshahi, H. Sugimoto, , R. Kalluri

This paper develops an engineered extracellular vesicles-based vaccine platform for combined mRNA and protein delivery, showing tumor regression and immune responses in preclinical models.

bioRxiv · Mar 14, 2024Immunology

Antigen-presenting type-I conventional dendritic cells facilitate curative checkpoint blockade immunotherapy in pancreatic cancer

K. K. Mahadevan, A. M. Dyevoich, Y. Chen, B. Li, H. Sugimoto, A. M. Sockwell, K. M. McAndrews, H. Wang, S. Shalapour, S. S. Watowich, R. Kalluri

The paper shows that type-I conventional dendritic cells enhance checkpoint blockade immunotherapy effectiveness in pancreatic cancer when combined with pancreatitis.

bioRxiv · Mar 5, 2023 · PreprintCancer Biology

Angiotensin II receptor inhibition ameliorates liver fibrosis and enhances hepatocellular carcinoma infiltration by effector T cells

L. Gu, Y. Zhu, M. Lee, A. Nguyen, N. T. Ryujin, J. Huang, S. Chamseddine, L. Xiao, Y. I. Mohamed, A. O. Kaseb, M. Karin, S. Shalapour

This study shows that losartan, an angiotensin II receptor inhibitor, reduces liver fibrosis and enhances T cell infiltration in HCC, improving response to PD-1 blockade.

bioRxiv · Mar 5, 2023 · PreprintCancer Biology

IRF1 regulates self-renewal and stress-responsiveness to support hematopoietic stem cell maintenance

A. J. Rundberg Nilsson, H. Xian, S. Shalapour, J. Cammenga, M. Karin

This study identifies IRF1 as a master regulator of hematopoietic stem cell (HSC) self-renewal and stress responses, showing its role in maintaining HSC function and its relevance in AML patient stratification.

bioRxiv · Jan 24, 2023Cell Biology