Author

J. Conway

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:clustering· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

A. Cheung· 1 shared A. Dhoot· 1 shared A. Imamovic· 1 shared A. K. Tewari· 1 shared A. Khosla· 1 shared A. Prakash· 1 shared A. Taylor-Weiner· 1 shared B. Hutter-Paier· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. Cheung

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Author profile →

5 papers

Recent·Most cited

Cell-type-specific nuclear morphology predicts genomic instability and prognosis in multiple cancer types

J. Abel, S. Jain, D. Rajan, H. Padigela, K. Leidal, A. Prakash, J. Conway, M. Nercessian, C. Kirkup, S. A. Javed, R. Biju, N. Harguindeguy, D. Shenker, N. Indorf, D. Sanghavi, , A. Taylor-Weiner

The paper develops a deep learning pipeline for nucleus segmentation and featurization in cancer histology, linking nuclear morphology to genomic instability and prognosis across multiple cancer types.

bioRxiv · May 15, 2023 · PreprintCancer Biology

Analysis of evolutionary dynamics and clonal architecture in prostate cancer

J. Conway, A. K. Tewari, S. Y. Camp, S. Han, J. Crowdis, M. X. He, Y. A. Nyame, S. H. AlDubayan, N. Schultz, Z. Szallasi, M. M. Pomerantz, M. L. Freedman, L. Fong, P. S. Nelson, M. Brown, , E. Van Allen

This study analyzes prostate cancer clonal architecture and evolutionary dynamics in 845 tumors, finding that Black patients have more monoclonal tumors but higher recurrence rates, and identifies new mutational signatures linked to subclones.

bioRxiv · Mar 23, 2023 · PreprintCancer Biology

Improved bioavailability of montelukast through a novel oral mucoadhesive film in humans and mice

J. Michael, D. M. de Sousa, J. Conway, E. Gonzalez-Labrada, R. Obeid, J. Tevini, T. Felder, B. Hutter-Paier, H. Zerbe, N. Paiement, L. Aigner

This study develops a mucoadhesive film formulation of montelukast that improves bioavailability in humans and mice, with detectable levels in cerebrospinal fluid.

bioRxiv · Nov 6, 2020Pharmacology & Toxicology

Clinical interpretation of integrative molecular profiles to guide precision cancer medicine

B. Reardon, N. D. Moore, N. Moore, E. Kofman, S. Aldubayan, A. Cheung, J. Conway, H. Elmarakeby, A. Imamovic, S. C. Kamran, T. Keenan, D. Keliher, D. J. Konieczkowski, D. Liu, K. Mouw, , E. M. Van Allen

This paper introduces MOAlmanac, a clinical interpretation algorithm that integrates genomic and transcriptional data to improve precision cancer treatment decisions by considering second-order molecular features.

bioRxiv · Sep 22, 2020Cancer Biology

Should virus capsids assemble perfectly? Theory and observation of defects

J. Spiriti, J. Conway, D. M. Zuckerman

The paper quantifies conditions for viral capsid defects using a statistical mechanics model and confirms ~15% defective particles in cryoEM studies.

bioRxiv · Mar 14, 2020Biophysics