Author

J. D. Baines

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

C. H. Birkenheuer· 2 shared L. E. M. Dunn· 2 shared C. Su· 1 shared F. Lu· 1 shared P. M. Lieberman· 1 shared R. Dufour· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 9 mutual co-author links

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2 shared papersMicrobiology

C. H. Birkenheuer

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3 papers

Recent·Most cited

Immediate early proteins of herpes simplex virus transiently repress viral transcription before subsequent activation

L. E. M. Dunn, C. H. Birkenheuer, R. Dufour, J. D. Baines

This study shows HSV-1 immediate early genes initially repress viral transcription before activating it, revealing a repressive phase in the lytic transcriptional cascade.

bioRxiv · Jun 13, 2022Microbiology

Reactivation of Epstein Barr Virus from Latency Involves Increased RNA Polymerase Activity at CTCF Binding Sites On The Viral Genome

L. E. M. Dunn, F. Lu, C. Su, P. M. Lieberman, J. D. Baines

This paper maps RNA polymerase activity during EBV latency and reactivation, finding that CTCF binding sites are key for early bidirectional transcription during reactivation.

bioRxiv · Nov 1, 2021Microbiology

The ICP22 protein of Herpes Simplex Virus 1 promotes RNA Polymerase II activity on Viral Immediate Early Genes

C. H. Birkenheuer, J. D. Baines

This study shows that HSV-1 ICP22 enhances RNA Polymerase II activity on viral immediate early genes, promoting transcription initiation and elongation, and is critical for sustaining viral DNA replication and later stages of infection.

bioRxiv · May 5, 2021Microbiology