Phage-specific immune responses impair efficacy of phage therapy targeting VRE in a murine model
J. D. Berkson, G. B. Allen, A. M. Schubert, K. E. Dunbar, M. P. Coryell, R. L. Sava, Y. Gao, C. E. Wate, J. L. Hastie, S. K. Zimmermann, P. E. Carlson
This study shows that phage-specific immune responses can reduce the effectiveness of phage therapy targeting VRE in mice, with different phages eliciting varying immune responses.
bioRxiv · Jan 19, 2023 · PreprintImmunology