A hand-off of DNA between archaeal polymerases allows high-fidelity replication to resume at a discrete intermediate three bases past 8-oxoguanine
M. T. Cranford, J. D. Kaszubowski, M. TRAKSELIS
The paper shows that after bypassing 8-oxoG lesions, DNA replication resumes at a specific +3 position through a hand-off between TLS PolY and HiFi PolB1.
bioRxiv · Jun 17, 2020Biochemistry