wet-lab / biochemical assay

This paper develops a PD-1 chimeric switch receptor T-cell platform that improves tumor targeting while reducing toxicity to normal cells in PD-L1-targeted therapies.

The paper investigates experience-dependent plasticity in somatostatin interneurons and identifies two-pore potassium (K2P) channels as a mechanism underlying this plasticity.

This study develops a synthetic cleavage module that selectively degrades pathogenic r(CUG) repeats in cells, reducing DM1-associated pathology without DNA damage.

This study shows that mitochondrial proteostasis stress causes a biphasic cortisol response, with mild stress increasing and severe stress decreasing cortisol production, linking mitochondrial function to steroidogenesis in Parkinson's disease models.

This study shows that Scn2a-deficient mice have altered serotonergic function and different behavioral responses to psilocybin compared to wild-type mice.

The paper introduces PRISM-Lys, a chemoproteomic method to quantitatively map lysine redox states, revealing site-specific changes during ferroptosis.

This study develops tetrasulfide-incorporated mesoporous silica nanoparticles to enhance mRNA delivery by optimizing morphology and chemistry, showing improved cellular uptake and mRNA stability.

This paper shows that delivering the anti-TGFβ peptide P144 via CAR-T cells enhances their efficacy in mesothelioma by recruiting neutrophils and remodeling the tumor microenvironment.

This study shows that implicit recalibration becomes flexible after prolonged training on novel sensorimotor mappings, allowing context-specific adaptation.

The paper identifies widespread readthrough transcription in human cells and shows that depletion of specific factors increases its extent.

This study identifies nutrient dependencies of intestinal Klebsiella pneumoniae and develops a probiotic consortium to restrict its expansion.

SEngEAR is a web platform for annotating senescent cells, visualizing communication networks, and comparing senescence signatures across datasets and contexts.

GraphExperiment provides an R/Bioconductor package to store and manipulate high-dimensional quantitative data alongside associated networks in a unified framework.

This study shows influenza virus uses its nucleoprotein to block RIG-I activation by host RNAs, thereby suppressing the antiviral response and enhancing viral replication.

The paper introduces synthetic tools to redirect and chemically control the Arg/N-degron pathway by modifying PRT1's substrate recognition and using nanobodies to induce ubiquitination.

The paper shows that glutaminolysis and mitochondrial metabolism are conditionally crucial for B cell differentiation and cytokine signaling, revealing metabolic regulation of plasma cell generation and cytokine receptor signaling.

The paper identifies an RNA-binding protein essential for female gamete development and sporozoite infectivity in Cryptosporidium by analyzing single-cell data and conducting conditional ablation experiments.

This study investigates the oligomerization and activation mechanism of the RPS4-RRS1 immune receptor complex in Arabidopsis, showing that effector recognition triggers conformational changes that enable NADase activity.

This study identifies IKKβ activation as a transient upstream signal triggered by efferocytosis that promotes tissue resolution through multiple downstream pathways.

The paper identifies a bacterial immune pathway where tRNA cleavage generates second messengers that trigger cell death via RNA-guided nuclease activity.

This study shows that MXRA8-dependent infection of PDGFRα+ mesenchymal cells by CHIKV increases vascular permeability, enabling hematogenous spread and joint swelling.

This study identifies cyanoquinoline-based HIPK4 inhibitors with nanomolar potency and reveals their cell-type-specific effects on HIPK4 proteostasis and autophagy.

This study identifies and characterizes monoclonal antibodies from rabbit B cells that bind intestinal bacteria, demonstrating their broad specificity and potential for therapeutic applications.

This study develops human spinal cord organoids and assembloids to model oligodendrocyte development and disease states, showing they recapitulate developmental signatures and cytokine-induced dysfunction seen in multiple sclerosis.

This paper introduces an in vivo TCE platform that depletes plasma cells in autoimmune dry eye models, showing efficacy and safety without ex vivo manufacturing.

This study identifies a genetic interaction between MCL1 and MARCHF5 in PEL cells, showing that MARCHF5 promotes cell survival by degrading NOXA, an antagonist of MCL1.

This paper identifies cereblon (CRBN) as a host factor that promotes influenza virus replication by degrading AMPK, shifting cellular metabolism to support viral growth.

The paper shows that MCA1 mechanosensitive channels mediate rapid inter-root signaling in Arabidopsis following mechanical injury.