Up-regulation of cholesterol synthesis by lysosomal defects requires a functional mitochondrial respiratory chain
F. Agostini, L. Pereyra, J. Dale, K. F. Yambire, S. Maglioni, A. Schiavi, N. Ventura, I. Milosevic, N. Raimundo
The paper identifies that lysosomal defects up-regulate cholesterol synthesis via mitochondrial respiratory chain interactions and Ca2+ retention, while mitochondrial defects down-regulate it.
bioRxiv · Mar 6, 2024Biochemistry