Deamidation in Moxetumomab Pasudotox Leading to Conformational Change and Immunotoxin Activity Loss
J. Wang, X. Lu, N. De Mel, A. Parupudi, S. Lin, X. Wang, J. Delmar, M. Pandey
The paper identifies deamidation at Asn-358 in moxetumomab pasudotox causing conformational changes and reduced immunotoxin activity.
bioRxiv · Sep 8, 2019Biophysics