Author

J. E. Deweese

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Biochemistry· 1

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Approach:experimental assay· 1

Frequent Co-Authors

C. T. Durham· 1 shared D. C. England· 1 shared E. Baxter· 1 shared E. C. Lisic· 1 shared J. R. Musselman· 1 shared L. A. Fielding· 1 shared X. Jiang· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

C. T. Durham

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1 paper

Recent·Most cited

Topoisomerase IIα C-terminal Domain Mutations and Catalytic Function

J. R. Musselman, D. C. England, L. A. Fielding, C. T. Durham, E. Baxter, X. Jiang, E. C. Lisic, J. E. Deweese

This study examines how mutations in the C-terminal domain of Topoisomerase IIα affect clamp closure and DNA cleavage, finding that some mutants show reduced activity and that Cu-APY-ETSC impacts DNA cleavage similarly to wild-type enzyme.

bioRxiv · Jul 29, 2023 · PreprintBiochemistry