BiochemistrybioRxivPreprint
Topoisomerase IIα C-terminal Domain Mutations and Catalytic Function
J. R. Musselman, D. C. England, L. A. Fielding…·J. E. Deweese
This study examines how mutations in the C-terminal domain of Topoisomerase IIα affect clamp closure and DNA cleavage, finding that some mutants show reduced activity and that Cu-APY-ETSC impacts DNA cleavage similarly to wild-type enzyme.
DOI 10.1101/2023.07.29.551120