IL-6 Trans-Signaling and Tumor-Muscle-Adipose Crosstalk Mediate Pancreatic Cancer Cachexia
J. E. Rupert, A. Bonetto, A. Narasimhan, Y. Liu, T. M. O'Connell, L. G. Koniaris, T. Zimmers
This study identifies IL-6 trans-signaling and tissue crosstalk as drivers of pancreatic cancer cachexia, showing disruption reduces fat and muscle wasting.
bioRxiv · Sep 16, 2020Cancer Biology