In vivo Imaging and Pharmacokinetics of Percutaneously Injected Ultrasound and X-ray Imageable Thermosensitive Hydrogel loaded with Doxorubicin versus Free Drug in Swine
J. F. Delgado, Ayele H. Negussie, Nicole Varble, Andrew S. Mikhail, Antonio Arrichiello, Tabea Borde, Laetitia Saccenti, Ivane Bakhutashvili, Joshua Owen, Robert Morhard, John W. Karanian, William F. Pritchard, Bradford J. Wood
This study evaluates a thermosensitive hydrogel loaded with doxorubicin for targeted drug delivery in swine, showing reduced systemic exposure and improved localization compared to free drug injection.
PLoS ONE · Dec 19, 2024Peer-reviewedBioengineering