PGC-1α regulates mitochondrial calcium homeostasis, SR stress and cell death to mitigate skeletal muscle aging
J. F. Gill, J. Delezie, G. Santos, S. McGuirk, S. Schnyder, S. Frank, M. Rausch, J. St-Pierre, C. Handschin
This study shows that PGC-1α improves mitochondrial function and reduces sarcoplasmic reticulum stress and cell death in aging skeletal muscle, thereby delaying aging effects.
bioRxiv · Oct 23, 2018Cell Biology