Author

C. Handschin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Organism:mouse· 4 Research Focus:gene regulatory network inference· 2 Assay:metabolomics· 2 Assay:proteomics· 2

Frequent Co-Authors

J. Delezie· 3 shared R. Furrer· 3 shared D. Ritz· 2 shared G. Santos· 2 shared A. B. Leuchtmann· 1 shared A. Boersch· 1 shared A. Krook· 1 shared A. S. Ham· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersPhysiology

J. Delezie

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Molecular control of endurance training adaptation in mouse skeletal muscle

R. Furrer, B. Heim, S. Schmid, K. J. V. Nordstrom, S. Dilbaz, D. Ritz, V. Adak, S. A. Steurer, J. Walter, C. Handschin

The paper identifies molecular changes in mouse skeletal muscle due to endurance training and shows how training status affects transcriptional and proteomic responses to acute exercise.

bioRxiv · Feb 18, 2023 · PreprintPhysiology

Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle

D. J. Ham, A. Boersch, K. Chojnowska, S. Lin, A. B. Leuchtmann, A. S. Ham, M. Thuerkauf, J. Delezie, R. Furrer, D. Burri, M. Sinnreich, C. Handschin, L. A. Tintignac, M. Zavolan, N. Mittal, M. A. Ruegg

This study shows that calorie restriction and rapamycin have distinct and additive effects on aging skeletal muscle gene expression and function in mice.

bioRxiv · May 28, 2021Physiology

Transcriptomic, proteomic and phosphoproteomic underpinnings of daily exercise performance and Zeitgeber activity of endurance training

G. Maier, J. Delezie, P. O. Westermark, G. Santos, D. Ritz, C. Handschin

The paper investigates how exercise timing affects circadian rhythms and endurance performance in mice, finding time-dependent differences in metabolic and signaling pathways.

bioRxiv · Oct 19, 2020Physiology

Branched-Chain Amino Acid Metabolism is Regulated by ERRα in Primary Human Myotubes and is Further Impaired by Glucose Loading in Type 2 Diabetes

R. J. O. Sjögren, D. Rizo-Roca, A. V. Chibalin, E. Chorell, R. Furrer, S. Katayama, J. Harada, H. K. R. Karlsson, C. Handschin, T. Moritz, A. Krook, E. Näslund, J. R. Zierath

This study shows that type 2 diabetes impairs BCAA catabolism, which is regulated by ERRα via PGC-1 in human myotubes, and glucose loading worsens this impairment.

bioRxiv · Jul 24, 2020Physiology

PGC-1α regulates mitochondrial calcium homeostasis, SR stress and cell death to mitigate skeletal muscle aging

J. F. Gill, J. Delezie, G. Santos, S. McGuirk, S. Schnyder, S. Frank, M. Rausch, J. St-Pierre, C. Handschin

This study shows that PGC-1α improves mitochondrial function and reduces sarcoplasmic reticulum stress and cell death in aging skeletal muscle, thereby delaying aging effects.

bioRxiv · Oct 23, 2018Cell Biology